What does patchwork mean? patchwork. Noun 1. A work, such as a blanket, composed of many different colors and shapes, sewn together to make an interesting whole. 2. Any kind of creation that utilizes many different aspects to create one, whole piece. patchwork. Verb 1. To create a patchwork from pieces of fabric. 2. To assemble from a variety of sources; to cobble together.